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Cerebral amyloid angiopathy(CAA)is characterized by cerebrovascular deposition of the amyloid B-peptide,leading to intracerebral hemorrhage in severe cases.Other than rare familial cases,the only identified risks for CAA are advancing age and accompanying Alzheimer's disease.In the cohort of CAA-associated cerebral hemorrhages,the apoE E4 allele frequency was 0. 40,significantly greater than the control frequency of 0.14.The increase in CAA remained even after controlling for the presence of Alzheimer's disease,suggesting that apoE E4 is a risk factor for CAA and CAA-related hemorrhage,independent of its association with Alzheimer's disease. |
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